Thursday, July 24, 2014

Computational Approaches to Memory and Plasticity - a great insight into neuroscience

I had the opportunity mostly thanks to Dr. Upinder S.Bhalla and Subhasis Ray to attend a 2-week-long course on neuroscience, more particularly on how memory is formed and what are the methods to computationally model this process. I'm staying in India at NCBS, where the conference took place, for more 3 weeks; at the moment I'm working in Upi's lab to optimize MOOSE by implementing some GPGPU code.

Photo taken at campus of NCBS - such greenery.

Monday, July 21, 2014

EEG data analysis of audio induced fear

My previous post ended with some statistics now I proceed to the analysis of the retrieved signals. The results and the measurement itself is rather instructive than useful and practical, so if you are interested in a working solution I have to disappoint you. I'm planning a measurement concept that is going to be much simpler and going to look at the problem from a different perspective. Also as I dived more into the literature, I found that there was no need for the 3-minute calm part, there was rather need for the measurements immediately before and after the effects played.

Hypothesis to test - frontal alpha asymmetry

Pattern of asymmetrical frontal EEG activity is found to distinguish positive (happiness, joy) from negative (fear, anger) emotions by Hell and Nitschke [James A. Coan, 2004]. Although, this hypothesis turned out to be false (at least other more supported hypothesis came), and instead some showed that it would be the indicator of valence - greater right frontal activity (which means greater left alpha power) compared to the left frontal activity indicates approach or engage stimulus and greater left frontal activity infer tendency to withdrawal stimulus. This is called Davidson's approach/withdrawal model [Davidson, 1993]. Here I should point out that activity is inversely related to alpha power, which means lower power reflects more activity and vice versa.

Alpha power means the values of the signal converted to frequency domain at 7 to 12 Hz. Here is the alpha power spatial representation of a fearful (withdrawal stimulus) person playing a horror game - not part of the main measurements. Here the alpha asymmetry model actually worked.